4-Methylumbelliferone sodium salt is a selective inhibitor of Hyaluronan (HA) synthesis. HA is a major component in the metastasis of malignant tumors.
Applications
It was used as a substrate to determine the idursulfase activity by a two-step fluorometric assay.
Biochem/physiol Actions
4-Methylumbelliferone Sodium Salt can suppress the expression of HA-synthase. It is also functions as an inhibitor via the depletion of UDP-glucuronic acid, the common substrate for HA synthesis.