0100-0186 is specific for the extracellular domain 1 of parathyroid hormone receptor 2. A member of the G-protein coupled receptor family, particularly abundant in the brain and pancreas .It may be responsible for PTH effects in a number of physiological systems and may play a significant role in pancreatic function. Binds parathyroid hormone, but shows very low affinity for PTHrP. This molecule is expressed in only a few tissues, and its structure and physiologic significance are poorly characterized. Type 2 receptor, is coupled to adenylyl cyclase, ligand binding induces a rise in intracellular concentration of cyclic AMP.
PTH-Rec 2 (99-116) 100%
PTH-Rec 1 (63-82) 0.06%
PTH-Rec 1 (562-580) 0.4%
Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Ig fraction prepared by ammonium sulphate precipitation
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
Immunogen
Synthetic peptide corresponding to the amino acids 99 - 116 of the parathyroid hormone receptor 2 molecule.
Approx. Protein Concentrations
IgG concentration 5.0 mg/ml
Buffer Solution
Phosphate buffered saline
Application
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visitwww.abdserotec.com/protocols.
Application Name
Yes
No
Not Determined
Suggested Dilution
ELISA
Western Blotting
1/20 - 1/100
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.
Storage
Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
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